Vacancies in Edinburgh Infectious Diseases

Current vacancies

Please click on the links below for further details of each post.  Vacancies are listed with closest application dates at the top.  Application should be submitted by 5 pm on the closing date unless otherwise specified



MRC Centre for Inflammation Research: Regius Chair of Medical Science

Applications are invited for the University’s prestigious Regius Chair of Medical Science, which is vacant following the departure of Professor John Iredale to a Pro-Vice Chancellor post at the University of Bristol.

We are seeking to appoint an outstanding medical scientist to the post. The major remit of the role is to provide outward-facing strategic leadership in medical research and innovation, supporting the University’s 2016 strategic plan, which identifies as Development themes influencing globally, contributing locally, partnership with industry and digital transformation/data. There will also be a requirement to be involved in enhancing eLearning and on-line teaching initiatives.

The postholder will report to the Head of Edinburgh Medical School and support the College Dean of Research. The Regius Chair will be a member of the College Research Committee.
If the successful applicant is clinically qualified we anticipate NHS Lothian will offer an honorary consultant contract.

Potential applicants are encouraged to contact the Head of Edinburgh Medical School, Professor Moira Whyte FMedSci (moira.whyte@ed.ac.uk; 0131 242 6561).

Job Purpose

We are seeking a medical scientist with a world-leading research track record and evidence of influencing policy at the highest level. Key objectives for the successful appointee will be to help increase, over five years, the School’s public research and innovation income by at least 50% and to help double industrial research income over that period.

Vacancy Details

  • For more information and to apply:  CLICK HERE
  • Vacancy Ref:  038752
  • Closing Date:  Friday 10 February 2017
  • Contact Person : Andrea Scott, 0131 242 6355, andrea.scott@ed.ac.uk
  • Grade/Pay Scale:  AC4, £82,616
  • Full time open ended contract

 


Division of Infection & Pathway Medicine: Research Fellow in Infection Medicine

The successful candidate will work on a MRC-funded project on the control of type III interferon expression and Herpes simplex virus type 1 replication by miR-200. The proposed work will require the use of a broad range of techniques (molecular and cell biology, virology/microbiology, immunology and biochemistry) investigating the functional mechanisms underlying type III interferon regulation in virus-infected cells. The successful candidate will be part of the research group led by Prof Jurgen Haas working on pathogen-host interactions that determine pathogenicity in a range of different viruses.

The applicant should hold a Ph.D. degree with relevant postgraduate research experience in virology/microbiology/infectious diseases and/or molecular biology.

Job Purpose
To contribute to a high quality research programme on type III interferon regulation, conduct original research and produce material for publication and dissemination. The aim of this project is to elucidate the mechanisms involved in the inhibition of HSV-1 by the cellular miRNAs that have been identified in our recent miRNA mimic and inhibitor screen. We will take a two-pronged approach, a broad approach to identify cellular genes targeted by anti-viral miRNAs and evaluate how they inhibit HSV-1 replication, and a focused approach on one miRNA family, miR-200, for which we already have preliminary evidence that it is involved in the regulation of an inhibitory cytokine, IFN-lamda. Understanding these mechanisms will be helpful for the development of novel anti-viral and anti-tumour therapeutics. Specific objectives are (i) to identify cellular genes that are regulated by antiviral miRNAs and evaluate how they inhibit HSV-1 replication, (ii) to evaluate the mechanisms by which miR-200 inhibits HSV-1 replication and induces IFN-lamda and (iii) To evaluate virus and tissue-specificity of antiviral miRNAs.

Vacancy Details

  • For more information and to apply:  CLICK HERE
  • Vacancy Ref:  038678
  • Closing Date:  Monday 20 February 2017
  • Contact Person : Jurgen Haas, juergen.haas@ed.ac.uk
  • Grade/Pay Scale:  UE07, £32,004 - £38,183
  • 35 hours per week fixed for 36 months

MRC Centre for Inflammation Research: Postdoctoral Research Fellow

We are recruiting a Postdoctoral Research Fellow. This post offers an exciting opportunity to join a team of investigators tackling one of the principle health care challenges facing modern medicine, namely the threat presented by antimicrobial resistant pathogens. The successful applicant will join a team in Edinburgh, contributing to the MRC AMR SHIELD, consortium, which also involves academic partners in Sheffield, Newcastle and Birmingham as well as several industry partners. The consortium will explore the potential of modulating phagocyte microbicidal mechanisms as a strategy with which to combat resistant bacteria.

Professor David Dockrell, Consortium Lead and principal investigator at the Centre for Inflammation Research, along with Edinburgh consortium colleagues, is now recruiting the Edinburgh staff for the consortium. The post-doctoral research fellow will set up a CRISPR screen and lead the validation of hits to identify novel regulators of microbicidal responses in phagocytes. They will work with academic and industry partners to develop therapeutic approaches to modulate the most promising targets in in vivo models and will work with other members of the consortium to apply innovative approaches to validating these. Validation in clinical samples and liaising with industry partners to refine targeting will be a key aspect of the project. You will need a PhD with relevant experience in immunology and infectious disease models while experience of in vivo infection models is desirable. Previous experience of genetic screens would also be desirable.

Job Purpose
This post offers an exciting opportunity to join a team of investigators tackling one of the principle health care challenges facing modern medicine, namely the threat presented by antimicrobial resistant pathogens. The successful applicant will join a team in Edinburgh, contributing to the MRC AMR SHIELD, consortium, which also involves academic partners in Sheffield, Newcastle and Birmingham as well as several industry partners. The consortium will explore the potential of modulating phagocyte microbicidal mechanisms as a strategy with which to combat resistant bacteria.

Vacancy Details

  • For more information and to apply:  CLICK HERE
  • Vacancy Ref:  038749
  • Closing Date:  Friday 24 February 2017
  • Contact Person : Professor David Dockrell, 0131 242 6582 (Sec Sonia Rafferty)
  • Grade/Pay Scale:  UE07, £32,004 - £38,183
  • 35 hours per week fixed until 28 February 2021

 

 


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