Vacancies in Edinburgh Infectious Diseases
Please click on the links below for further details of each post. Vacancies are listed with closest application dates at the top. Application should be submitted by 5 pm on the closing date unless otherwise specified
- Centre For Inflammation Research - Chancellor's Fellow: Closing date Thursday 4 May 2017
- The Roslin Institute - Research Fellow: Closing date Tuesday 9 May 2017
- Institute of Cell Biology - Postdoctoral Research Associate: Closing date Friday 19 May 2017
Chancellor’s Fellowship– MRC University of Edinburgh Centre for Inflammation Research
The College of Medicine and Veterinary Medicine, part of the University of Edinburgh, a global top 20 University located in one of the world`s finest cities, is keen to attract early career researchers for appointment as Chancellor’s Fellows. Applications are welcomed from individuals with expertise in infection medicine in a global health context and in particular with expertise in systmes level approaches or disease modelling in the following areas
Systems biology approaches to pathogen evolution and diversity
Genetic epidemiology of infections in animals and man
Microbiome and metagenomics
Application of these approaches to tackle AMR, vaccine development or pathogenicity studies.
These 5-year Fellowships are intended to support candidates at the start of their independent academic careers. Subject to satisfactory review at the end of year 4, Fellows will then move to a standard University academic open-ended contract. It is anticipated that most appointees will be successful in obtaining an open-ended contract.
To undertake research in line with the research strategy of the host School/Institute/Centre, as well as of the University and to contribute to the School’s academic administration and teaching. To develop the skills and attributes required of a full member of the Academic staff of the University.
- For more information and to apply: CLICK HERE
- Vacancy Ref: 039646
- Closing Date: Thursday 4 May 2017
- Contact Person : Geraldine Shiels, email@example.com 0131 242 7441
- Grade/Pay Scale: UE08/UE09, £39,324 - £55,998
- 35 hours per week for 5 years.
A 6 month post-doctoral research position has become available at The Roslin Institute, the University of Edinburgh, under the supervision of Finn Grey. The purpose of the job is to undertake research on the functional role of microRNAs expressed by the herpes virus human cytomegalovirus. The research will focus mainly on the identification of miRNA target genes and determination of the functional relevance of these targets in relation to viral infection.
You should have post-graduate experience with a PhD or PhD near completion in a relevant subject area. A strong knowledge base in virology and/or microRNA biology is preferred but not essential. Experience in the use of molecular biological techniques, bio-imaging, virology and cell culture techniques is preferable.
The position is available on a fixed term basis for a period of 6 months (maternity cover).
Informal enquiries should be addressed to firstname.lastname@example.org
The purpose of the job is to undertake research on the functional role of microRNAs expressed by the herpes virus human cytomegalovirus. The research will focus mainly on the identification of miRNA target genes and determination of the functional relevance of these targets in relation to viral infection. The work builds on previous research in this area, in particular the use of RISC-IP analysis for the identification of miRNA target genes. The overall theme of the four year project will be to identify evolutionary conserved cellular and viral targets of viral encoded miRNAs. This project is based on preliminary data we have from RISC-IP analysis of HCMV infected fibroblast cells. Using this technique we have identified multiple cellular targets of HCMV encoded miRNAs. Part of the project will be to confirm these targets and determine why the virus targets these genes and what role they play in the biology of the virus. A number of the genes have links to viral biology, although not directly to HCMV, where as others appear to be novel as far as involvement in virus host interactions. The work would involve additional RISC-IP analysis which involves many molecular techniques as well as the use of microarray technology. Confirmation of the target genes will require training in core techniques used in miRNA research as well as general training in virology techniques.
- For more information and to apply: CLICK HERE
- Vacancy Ref: 039652
- Closing Date: Tuesday 9 May 2017
- Contact Person : Jane Anderson, email@example.com 0131 651 7482
- Grade/Pay Scale: UE07, £32,004 - £38,183
- 35 hours per week fixed from for 6 months maternity cover.
A post-doctoral research associate is required with demonstrated skills in virology, microscopy, and molecular biology. Particularly, the candidate should have experience with cloning and modifying viral and host cell genomes, preparing viruses for infection, tissue culture of mammalian cells, performing infections with human and or murine viruses, viral plaque and titre assays, investigating partners by pulldowns, super resolution light microscopy, electron microscopy, and protein, RNA and DNA isolation for Western, qRT-PCR and ChIP-seq. Experience with isotope and fluorescence in situ hybridization approaches is also necessary. Candidates with previous direct experience working with human herpes simplex virus (HSV-1) or human herpesvirus 6 (HHV-6) and who have worked with primary human cells, particularly muscle, blood and neurons will be given preference. The Schirmer laboratory has identified many tissue-specific nuclear envelope transmembrane proteins (NETs) and run these in screens to identify different subsets that affect spatial genome organization, cytoskeletal organization, nuclear size regulation, innate immune response signaling, cAMP signaling, calcium signaling, and herpesvirus egress through the nuclear envelope. The primary project will involve studying host cell proteins contributing to herpesvirus nuclear egress and how they interact with the virus-encoded US3, UL31 and UL34 proteins as well as general radial nuclear organisation changes in infected cells with respect to NET function. Effects of viral infection on innate immunity will also be investigated. Additionally, the candidate will be expected to contribute their in situ hybridization experience to other projects in the lab on gene positioning NETs and potentially give minor support to collaborations investigating cAMP or Ca2+ signaling functions at the nuclear envelope. Post is funded until 31/07/18 in the first instance.
The Nuclear envelope is one of the most important signaling nodes in the cell, and the Schirmer lab has identified many tissue-specific nuclear envelope transmembrane proteins (NETs) for which roles are being investigated. In particular, we found NETs responsible for spatial genome organization and cAMP and Ca2+ signaling that are also mutated in patients with Emery-Dreifuss muscular dystrophy (EDMD) and need to work out their mechanism of action. We also found NETs involved in both herpesvirus nuclear egress and transmission of innate immune responses, that we are investigating for how they interact with the nuclear membrane and nuclear pore complexes (NPCs).
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