Easter Bush Research Consortium Seminar: Jim Kaufman ( University of Cambridge) - Generalists & specialists: a new view of how MHC molecules fight infectious disease

  • Title:  Generalists & specialists: a new view of how MHC molecules fight infectious disease
  • When:  Wednesday 22 November 2017
  • Time:  1 pm
  • Location:  Roslin Institute Auditorium, The Roslin Institute, Easter Bush Campus, Midlothian, EH25 9RG
  • Speaker:  Jim Kaufman, University of Cambridge
  • Host: Mark Stevens (II)

Summary

In comparison to the MHC of typical mammals, the chicken MHC is simple and compact, with a single dominantly-expressed class I molecule that can determine the immune response. In addition to providing useful information for the poultry industry and allowing insights into the evolution of the adaptive immune system, the simplicity of the chicken MHC has allowed discovery of phenomena that are more difficult to discern in the more complicated mammalian systems. In this seminar, I present the new concept that poorly-expressed promiscuous class I alleles act as generalists to protect from a wide variety of infectious pathogens, while highly-expressed fastidious class I alleles can act as specialists to protect against new and dangerous pathogens in both chickens and humans.

 

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