Centre for Immunity, Infection and Evolution seminar: Etienne Pays (Laboratory 
of
 Molecular
 Parasitology,
 Université
 Libre 
de Bruxelles
, Belgium)



  • When:  Friday 24 May 2013
  • When:  4 - 5 pm
  • Location:  Lecture theatre 3, Ashworth Labs, Kings Buildings
  • Title:  Molecular 
dialogue 
between
 African 
trypanosomes and
 man

This seminar forms part of the Edinburgh Kinetoplastid Group Meeting - ALL WELCOME

Professor
 Pays’
 seminar
 will
 be
 a
 review
 on
 what
 is
 known
 about
 the
 mutual
 adaptations
 between
 African
 trypanosomes
 and
 humans.
 He
 will
 summarize
 the
 current
 knowledge
 about
 human
 innate
 immunity
 against
 T.
 b.
 brucei,
 the
 mechanisms
 of
 resistance 
of
 T.
b.
rhodesiense
 and
 T.
b.
gambiense 
to
 this immunity,
 and 
the
 adaptations
 having 
allowed
 some 
humans 
to 
resist 
T.
b.
rhodesiense.

  Prof
 Pays
 will
 also
 talk
 about
 his
 group’s
 recent
 findings
 on
 the
 mechanisms
 of
 T.
gambiense 
resistance 
to 
human 
serum.

 


Etienne
 Pays
 is
 Director
 of
 the
 Laboratory
 of
 Molecular
 Parasitology
 and
 a
 professor
 at
 the
 Université
 Libre
 de
 Bruxelles
 (Belgium).
 He
 and
 his
 co‐workers
 study
 the
 mechanisms
 of
 antigenic
 variation
 by
 African
 trypanosomes,
 as
 well
 as
 the
 components 
and
 mechanisms 
that 
allow 
these
 parasites 
to
 adapt
 to 
the 
host.



For
 more information please
 visit
 Professor
 Pays’
 website:


Some recent publications

  • Adenylate
 cyclases
 of
 Trypanosoma
 brucei
 inhibit 
the 
innate 
immune 
response of
 the
 host.
 Salmon 
D,
 Vanwalleghem 
G,
 Morias 
Y,
 Denoeud 
J,
 Krumbholz 
C,
 Lhommé 
F,
 Bachmaier 
S, 
Kador 
M, Gossmann 
J,
 Dias 
FB,
 De
Muylder 
G,
Uzureau 
P,
 Magez
 S,
 Moser 
M,
 De
Baetselier
 P,
 Van Den
 Abbeele 
J, 
Beschin
 A, Boshart
 M,
 Pays
E.
 Science.
 2012


  • Association 
of 
trypanolytic
 ApoL1
 variants
 with
 kidney disease 
in
 African
 Americans.
  Genovese 
G,
 Friedman DJ,
 Ross
 MD,
 Lecordier L,
 Uzureau 
P,
 Freedman 
BI,
 Bowden
 DW, 
Langefeld
 CD,
 Oleksyk
 TK,
 Uscinski 
Knob
 AL,
 Bernhard 
AJ, Hicks 
PJ,
 Nelson
 GW,
Vanhollebeke
 B,
 Winkler
 CA,
 Kopp 
JB,
 Pays 
E,
 Pollak 
MR.
 Science.
 2010

 

  • Human 
innate immunity against
 African 
trypanosomes.
 Pays 
E,
 Vanhollebeke
 B.
 Curr
 Opin 
Immunol.
 2009

 

     
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