Featured publications

We are starting a series of articles featuring recent publications from Edinburgh Infectious Diseases members.  Please check back here often to read more about our latest work.

New in 2014    New in 2013

A new study published by researchers from the Division of Pathway Medicine at the University of Edinburgh highlights the risk of infection with Rickettsia africae for travellers to sub-Saharan Africa. 

The paper from Vincenzo Lorusso, Karolina Anna Gruszka, Ayodele Majekodunmi, Sue Welburn, and Kim Picozzi in the Division of Pathway Medicine, and their colleague Augustine Igweh at the Nigerian Institute for Trypanosomiasis Research, VOM, Jos, Plateau State, Nigeria, has just been published in the October 2103 volume of Emerging Infectious Diseases Journal:

- See more at: http://sbsweb2.bio.ed.ac.uk/eid/news/new-study-shows-bacteria-cause-afri...

New in 2014

New study from Edinburgh researchers in the Lancet shows statins could bring cough relief for lung disease patients

  • Read the paper at this link:  Pallavi Mandal, James D Chalmers, Catriona Graham, Catherine Harley, Manjit K Sidhu, Catherine Doherty, John W Govan, Tariq Sethi, Donald J Davidson, Adriano G Rossi, Adam T Hill; Atorvastatin as a stable treatment in bronchiectasis: a randomised controlled trial; Lancet Respiratory Medicine (2014), doi:10.1016/S2213-2600(14)70050-5.

New class of drug could curb antibiotic resistance, new study suggests

New paper from Amy Pedersen (IEB) shows that parasites in humans influence each other via shared food sources

  • Griffiths EC1, Pedersen AB, Fenton A, Petchey OL. Analysis of a summary network of co-infection in humans reveals that parasites interact most via shared resources. Proc Biol Sci. 2014 Mar 11;281(1782):20132286. doi: 10.1098/rspb.2013.2286. Print 2014. http://www.ncbi.nlm.nih.gov/pubmed/24619434

Interpreting bacteria’s complex language could aid infection fight

  • Cornforth DM1, Popat R, McNally L, Gurney J, Scott-Phillips TC, Ivens A, Diggle SP, Brown SP. Combinatorial quorum sensing allows bacteria to resolve their social and physical environment. Proc Natl Acad Sci U S A. 2014 Mar 4. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24594597

New paper in Nature from Andrew Rambaut (Inst. Evolutionary Biology) that reconstructs the evolutionary tree of influenza viruses

  • Worobey M1, Han GZ1, Rambaut A2. A synchronized global sweep of the internal genes of modern avian influenza virus. Nature. 2014 Feb 16. doi: 10.1038/nature13016. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24531761

New study in Nature Communications shows that common form of malaria originated in Africa

Researchers from Edinburgh Infectious Diseases have made vital steps forward in malaria vaccine development that pave way for protective therapy

  • Cowan GJ1, Bockau U2, Eleni-Muus J2, Aldag I2, Samuel K3, Creasey AM1, Hartmann MW2, Cavanagh DR1. A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila. PLoS One. 2014 Jan 29;9(1):e87198. doi: 10.1371/journal.pone.0087198. eCollection 2014. http://www.ncbi.nlm.nih.gov/pubmed/24489871

Genetic clues to TB-resistant cattle from researchers at the Roslin Institute

  • Bermingham ML1, Bishop SC1, Woolliams JA1, Pong-Wong R1, Allen AR2, McBride SH2, Ryder JJ3, Wright DM3, Skuce RA4, McDowell SW2, Glass EJ1. Genome-wide association study identifies novel loci associated with resistance to bovine tuberculosis. Heredity (Edinb). 2014 Feb 5. doi: 10.1038/hdy.2013.137. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/24496092

Drug alternatives to antibiotics may not be perfect, study shows

  • Vale PF1, Fenton A2, Brown SP1. Limiting damage during infection: lessons from infection tolerance for novel therapeutics. PLoS Biol. 2014 Jan;12(1):e1001769. doi: 10.1371/journal.pbio.1001769. Epub 2014 Jan 21. http://www.ncbi.nlm.nih.gov/pubmed/24465177

A new discovery by scientists from Edinburgh Infectious Diseases could help combat the spread of sleeping sickness

  • Mony BM1, MacGregor P1, Ivens A2, Rojas F2, Cowton A2, Young J2, Horn D3, Matthews K2. Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei. Nature. 2014 Jan 30;505(7485):681-5. doi: 10.1038/nature12864. Epub 2013 Dec 15. http://www.ncbi.nlm.nih.gov/pubmed/24336212

Research from The Roslin Institute offers new insights into why vCJD appears to mainly affect the young

  • Brown KL1, Mabbott NA. Evidence of subclinical prion disease in aged mice following exposure to bovine spongiform encephalopathy. J Gen Virol. 2014 Jan;95(Pt 1):231-43. doi: 10.1099/vir.0.058958-0. Epub 2013 Oct 15. http://www.ncbi.nlm.nih.gov/pubmed/24123519

New in 2013

Clean living is a luxury wild animals can’t afford, Edinburgh study suggests

Domestic pigs are acting as potential sources of sleeping sickness in sub-Saharan Africa

  • Hamill LC, Kaare MT, Welburn SC, Picozzi K1. Domestic pigs as potential reservoirs of human and animal trypanosomiasis in Northern Tanzania. Parasit Vectors. 2013 Nov 9;6(1):322. doi: 10.1186/1756-3305-6-322. http://www.ncbi.nlm.nih.gov/pubmed/24499540

Holograms offer hope in fight against malaria, study from Edinburgh Infectious Diseases researchers suggests

  • Wilson LG1, Carter LM, Reece SE. High-speed holographic microscopy of malaria parasites reveals ambidextrous flagellar waveforms. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18769-74. doi: 10.1073/pnas.1309934110. Epub 2013 Nov 5. http://www.ncbi.nlm.nih.gov/pubmed/24194551

New study shows bacteria that cause African tick bite fever now infect ticks in Uganda

  • Lorusso V, Gruszka KA, Majekodunmi A, Igweh A, Welburn SC, Picozzi K. Rickettsia africae in Amblyomma variegatum ticks, Uganda and Nigeria. Emerg Infect Dis. 2013 Oct;19(10):1705-7. doi: 10.3201/eid1910.130389. http://www.ncbi.nlm.nih.gov/pubmed/24050756

Researchers in the Division of Pathway Medicine have identified why some people are susceptible to core sores

  • Griffiths SJ1, Koegl M, Boutell C, Zenner HL, Crump CM, Pica F, Gonzalez O, Friedel CC, Barry G, Martin K, Craigon MH, Chen R, Kaza LN, Fossum E, Fazakerley JK, Efstathiou S, Volpi A, Zimmer R, Ghazal P, Haas J. A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication. PLoS Pathog. 2013;9(8):e1003514. doi: 10.1371/journal.ppat.1003514. Epub 2013 Aug 8. http://www.ncbi.nlm.nih.gov/pubmed/23950709

New study from Edinburgh Infectious Diseases shows cattle can be a source of MRSA in people

  • Spoor LE1, McAdam PR, Weinert LA, Rambaut A, Hasman H, Aarestrup FM, Kearns AM, Larsen AR, Skov RL, Fitzgerald JR. Livestock origin for a human pandemic clone of community-associated methicillin-resistant Staphylococcus aureus. MBio. 2013 Aug 13;4(4). pii: e00356-13. doi: 10.1128/mBio.00356-13. http://www.ncbi.nlm.nih.gov/pubmed/23943757

New study from Edinburgh Infectious Diseases has significant implications for tick control in Sub-Saharan Africa

  • Lorusso V1, Picozzi K, de Bronsvoort BM, Majekodunmi A, Dongkum C, Balak G, Igweh A, Welburn SC. Ixodid ticks of traditionally managed cattle in central Nigeria: where Rhipicephalus (Boophilus) microplus does not dare (yet?). Parasit Vectors. 2013 Jun 7;6:171. doi: 10.1186/1756-3305-6-171. http://www.ncbi.nlm.nih.gov/pubmed/23758913

Treating infection may have sting in the tail, shows new parasite study from Edinburgh Infectious Diseases

  • Knowles SC1, Fenton A, Petchey OL, Jones TR, Barber R, Pedersen AB. Stability of within-host-parasite communities in a wild mammal system. Proc Biol Sci. 2013 May 15;280(1762):20130598. doi: 10.1098/rspb.2013.0598. Print 2013 Jul 7. http://www.ncbi.nlm.nih.gov/pubmed/23677343

Recent study at the Roslin Institute shows how Salmonella colonises the gut

  • Chaudhuri RR1, Morgan E, Peters SE, Pleasance SJ, Hudson DL, Davies HM, Wang J, van Diemen PM, Buckley AM, Bowen AJ, Pullinger GD, Turner DJ, Langridge GC, Turner AK, Parkhill J, Charles IG, Maskell DJ, Stevens MP. Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals. PLoS Genet. 2013 Apr;9(4):e1003456. doi: 10.1371/journal.pgen.1003456. Epub 2013 Apr 18. http://www.ncbi.nlm.nih.gov/pubmed/23637626

Researchers at the Moredun Research Institute make major breakthrough in the war against worms

  • Nisbet AJ1, McNeilly TN, Wildblood LA, Morrison AA, Bartley DJ, Bartley Y, Longhi C, McKendrick IJ, Palarea-Albaladejo J, Matthews JB. Successful immunization against a parasitic nematode by vaccination with recombinant proteins. Vaccine. 2013 Aug 20;31(37):4017-23. doi: 10.1016/j.vaccine.2013.05.026. Epub 2013 May 22. http://www.ncbi.nlm.nih.gov/pubmed/23707168

Research from Edinburgh Infectious Diseases estimates that childhood deaths from diarrhoea and pneumonia could be halved by 2025

A series of three papers published in the Lancet

  • Walker CL1, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O'Brien KL, Campbell H, Black RE. Global burden of childhood pneumonia and diarrhoea. Lancet. 2013 Apr 20;381(9875):1405-16. doi: 10.1016/S0140-6736(13)60222-6. Epub 2013 Apr 12. http://www.ncbi.nlm.nih.gov/pubmed/23582727
  • Bhutta ZA1, Das JK, Walker N, Rizvi A, Campbell H, Rudan I, Black RE; Lancet Diarrhoea and Pneumonia Interventions Study Group. Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost? Lancet. 2013 Apr 20;381(9875):1417-29. doi: 10.1016/S0140-6736(13)60648-0. Epub 2013 Apr 12. http://www.ncbi.nlm.nih.gov/pubmed/23582723
  • Chopra M1, Mason E, Borrazzo J, Campbell H, Rudan I, Liu L, Black RE, Bhutta ZA. Ending of preventable deaths from pneumonia and diarrhoea: an achievable goal. Lancet. 2013 Apr 27;381(9876):1499-506. doi: 10.1016/S0140-6736(13)60319-0. Epub 2013 Apr 12. http://www.ncbi.nlm.nih.gov/pubmed/23582721

Edinburgh Infectious Diseases scientists at the Roslin Institute tackle deadly elephant virus

  • Wilkie GS1, Davison AJ, Watson M, Kerr K, Sanderson S, Bouts T, Steinbach F, Dastjerdi A. Complete genome sequences of elephant endotheliotropic herpesviruses 1A and 1B determined directly from fatal cases. J Virol. 2013 Jun;87(12):6700-12. doi: 10.1128/JVI.00655-13. Epub 2013 Apr 3. http://www.ncbi.nlm.nih.gov/pubmed/23552421

A new viewpoint on a critical enzyme

  • Morgan HP1, O'Reilly FJ, Wear MA, O'Neill JR, Fothergill-Gilmore LA, Hupp T, Walkinshaw MD. M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5881-6. doi: 10.1073/pnas.1217157110. Epub 2013 Mar 25. http://www.ncbi.nlm.nih.gov/pubmed/23530218

Immune finding aids quest for vaccines to beat tropical infections

  • van der Werf N1, Redpath SA, Azuma M, Yagita H, Taylor MD. Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection. PLoS Pathog. 2013 Mar;9(3):e1003215. doi: 10.1371/journal.ppat.1003215. Epub 2013 Mar 14. http://www.ncbi.nlm.nih.gov/pubmed/23516361

New study from Institute of Evolutionary Biology shows that eating well could help spread disease

  • Vale PF1, Choisy M, Little TJ. Host nutrition alters the variance in parasite transmission potential. Biol Lett. 2013 Feb 13;9(2):20121145. doi: 10.1098/rsbl.2012.1145. Print 2013 Apr 23. http://www.ncbi.nlm.nih.gov/pubmed/23407498

Protein discovery could hold key to understanding autoimmune diseases

  • Brownlie RJ1, Miosge LA, Vassilakos D, Svensson LM, Cope A, Zamoyska R. Lack of the phosphatase PTPN22 increases adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci Signal. 2012 Nov 27;5(252):ra87. doi: 10.1126/scisignal.2003365. http://www.ncbi.nlm.nih.gov/pubmed/23193160

Global study reveals impact of pneumonia on world's children

  • Nair H1, Simões EA, Rudan I, Gessner BD, Azziz-Baumgartner E, Zhang JS, Feikin DR, Mackenzie GA, Moïsi JC, Roca A, Baggett HC, Zaman SM, Singleton RJ, Lucero MG, Chandran A, Gentile A, Cohen C, Krishnan A, Bhutta ZA, Arguedas A, Clara AW, Andrade AL, Ope M, Ruvinsky RO, Hortal M, McCracken JP, Madhi SA, Bruce N, Qazi SA, Morris SS, El Arifeen S, Weber MW, Scott JA, Brooks WA, Breiman RF, Campbell H; Severe Acute Lower Respiratory Infections Working Group. Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet. 2013 Apr 20;381(9875):1380-90. doi: 10.1016/S0140-6736(12)61901-1. Epub 2013 Jan 29. http://www.ncbi.nlm.nih.gov/pubmed/23369797

New study from Anura Rambukkana shows that leprosy bacteria can promote host cell reprogramming

  • Masaki T1, Qu J, Cholewa-Waclaw J, Burr K, Raaum R, Rambukkana A. Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection. Cell. 2013 Jan 17;152(1-2):51-67. doi: 10.1016/j.cell.2012.12.014. http://www.ncbi.nlm.nih.gov/pubmed/23332746

Fresh insight into the immune system could lead to better understanding of diseases that occur when the immune system fails. - See more at: http://sbsweb2.bio.ed.ac.uk/eid/featured-paper-better-understanding-auto...

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