Scottish TSE Network Annual Meeting - Roslin Institute


Programme


Day 1: Chronic Wasting Disease (CWD) pathogenesis and transmissibility

10 November 2014, 13:30 - 16:30
Chair: Professor Jean Manson, The Roslin Institute

13:30 - 14:00 Dr Candace Mathiason, Colorado State University, USA

  • Pathogenesis of CWD

14:00 - 14:30 Dr. Jürgen A. Richt, College of Veterinary Medicine, Kansas State University

  • Epidemiology and diagnostics of CWD

14:30 - 15:00 Coffee

15:00 - 15:15 Marcelo Barria, Young Researcher Talk, The National CJD Research and Surveillance Unit

  • Exploring the zoonotic potential of animal prions in vitro

15:15 - 15:45 Dr Ermias Belay, Centers for Disease Control and Prevention, USA

  • Cross-species transmission of chronic wasting disease

15:45 - 16:30 Discussion


Day 2: Amyloidogenesis in vitro and in vivo

11 November 2014, 9:00 - 17:00
Chair: Dr Mark Head, National CJD Research and Surveillance Unit; Chair: Professor Nora Hunter, The Roslin Institute

9:00 - 9:10 Dr Mark Head, National CJD Research and Surveillance Unit

  • Introductory Remarks

Session 1: Mechanisms of amyloid formation in vitro

9:10 - 9:40 Professor Chris Dobson, University of Cambridge, UK

  • Amyloidogenic protens (title to follow)

9:40 - 10:10 Dr Byron Caughey, National Institute of Allergy and Infectious Diseases, USA

  • Structure and detection of prions

10:10 - 10:40 Discussion

10:40 - 11:10 Coffee

Session 2: Understanding prion disease mechanisms

11:10 - 11:30 James Alibhai, Young Researcher Talk, The Roslin Institute

  • Misfolded prion protein alone is not sufficient to trigger neurodegeneration

11:30 - 12:00 Dr Andy Gill, The Roslin Institute

  • Exploiting PrP misfolding pathways to understand potential mechanisms of disease

12:00 - 12:30 Discussion

12:30 - 13:30 Lunch

Session 3: Practical applications: diagnostics and therapeutics

13:30 - 14:00 Dr Alison Green, The National CJD Research and Surveillance Unit

  • RT-QuIC as a CSF test for CJD

14:00 - 14:30 Dr Candace Mathiason, Colorado State University, USA

  • Detection and characterization of blood-born prions

14:30 - 15:00 Coffee

15:00 - 15:30 Professor Gianluigi Zanusso, University of Verona, Italy

  • Intravital Creutzfeldt-Jakob disease diagnosis by nasal brushing

15:30 - 16:00 Dr Maria Herva, University of Cambridge, UK

  • Studying Parkinson as a prion disease

16:00 - 16:30 Discussion

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