Holograms offer hope in fight against malaria, study from Edinburgh Infectious Diseases researchers suggests

Scientists have developed a 3D filming technique that could help inform research to stem the spread of malaria.

Creating moving digital holograms of malaria sperm has given researchers fresh insights into the behaviour of these tiny life forms.  Understanding how malaria parasites mate could pave the way for improved prevention and control of this deadly disease, which poses a threat to half of the world’s population.

Malaria parasites mate in the gut of mosquitoes, and people can catch the disease when they are bitten by these infected, blood-sucking insects. 

Scientists from the Institute of Evolutionary Biology at the University of Edinburgh, and the Rowland Institute at Harvard University were able to see that malaria sperm move in an irregular, lopsided corkscrew motion, which enables them to twist to the left or the right, as well as go forwards and backwards. This motion is thought to help the sperm swim between red blood cells to find female mates.

Malaria sperm use microscopic structures, known as flagella, to swim. These structures are important because they are used by many parasites to invade parts of the body. They also perform essential roles in embryonic development, reproduction, and nutrient uptake in all animals. Scientists say the simple structure of the malaria sperm makes it an excellent model system in which to study flagella in animals.

Dr Sarah Reece, Royal Society Fellow at the University of Edinburgh and one of the authors of the study, said:

Findings gained using our unique system provide us with a better understanding of how malaria parasites mate and spread this deadly disease, and have revealed that malaria sperm, and similar organisms, have greater freedom of movement than was previously thought.”

The study, published in the Proceedings of the National Academy of Sciences, was funded by the Rowland Institute at Harvard, the Natural Environmental Research Council, the Wellcome Trust, the Royal Society, and the University of Edinburgh.

For further information, please contact:

See coverage of this story elsewhere in the press:

Story tags: 

Please tell us what you think about this website !

What do you think of the Edinburgh Infectious Diseases website?  We would be very grateful if you could spare 2 minutes to help us improve the useability and look of our pages. Thank you for your help !