New study from University of Edinburgh shows that social networking is key to helping bugs spread

Fresh discoveries about how bacteria co-operate with each other when causing infection could help scientists identify animal diseases that might transmit to people.

Bugs that can co-operate best with each other are most likely to be able to jump to new species, including humans, a new study shows. 

Bacteria interact by releasing molecules to help them adapt to their environment – for example, when killing competing infections in their victim. They co-ordinate these actions by releasing tiny amounts of chemicals as signals.

Bacteria that can co-operate to create an environment in which they can thrive, are potentially able to infect lots of different species, including humans. For example, the image on the right is of Pseudomonas aeruginosa bacteria growing cooperatively on an agar plate - it is the most common cause of burn infections in humans and is the most frequent coloniser of medical devices such as catheters.  Discovering why some organisms are better equipped to infect more species than others – and therefore could affect humans – could be valuable in predicting and managing health threats.

Most new human infections arise from diseases that transmit from animals to humans. Many of these cause serious infections and are difficult to control, such as anthrax and the superbug MRSA.

Research from Sam Brown's lab at the University of Edinburgh used a combination of mathematical models and scientific analysis of genetic code in almost 200 types of bacteria. They found that those bugs that carry lots of genes that help them to co-operate are best equipped to adapt to various environments.

Luke McNally from the Centre for Immunity, Infection and Evolution at the University of Edinburgh, who led the study, said:

Humans have been able to colonise almost all of their planet by collectively modifying the environment to suit themselves. Our study shows bugs try to do the same – co-operation is important for the spread of bacteria to new species.”

The study, published in the journal Nature Communications, was carried out in collaboration with the University of Glasgow.  It was supported by the Wellcome Trust, the Engineering and Physical Sciences Research Council and the Royal Society.

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