New paper published: Beyond killing: can we find new ways to manage infection?

A paper on innovative approaches to manage disease without traditional antibiotics will be published in Evolution, Medicine, and Public Health.

The paper is an output of the symposium hosted in 2013 by the University of Edinburgh's Centre for Immunity, Infection and Evolution.

Pedro F. Vale1, 2, Luke McNally1, 2, Andrea Doeschl-Wilson5, Kayla C. King4, Roman Popat,1,2 Maria R. Domingo-Sananes3, Judith E. Allen1,6, Miguel P. Soares7, Rolf Kümmerli8

1. Centre for Immunity, Infection and Evolution, University of Edinburgh; 2. Institute of Evolutionary Biology, University of Edinburgh; 3. Institute for Genetics and Development of Rennes, France; 4. Department of Zoology, University of Oxford; 5. The Roslin Institute and R(D)SVS, University of Edinburgh; 6. Institute of Immunology and Infection Research, University of Edinburgh; 7. Instituto Gulbenkian de Ciência, Oeiras, Portugal; 8. Department of Plant and Microbial Biology, University of Zürich, Switzerland

The antibiotic pipeline is running dry and infectious disease remains a major threat to public health. An efficient strategy to stay ahead of rapidly adapting pathogens should include approaches that replace, complement, or enhance the effect of both current and novel antimicrobial compounds. In recent years, a number of innovative approaches managing disease without the aid of traditional antibiotics and without eliminating the pathogens directly have emerged. These include disabling pathogen virulence-factors, increasing host tissue damage control, or altering the microbiota to provide colonisation resistance, immune resistance or disease tolerance against pathogens.

The paper discusses the therapeutic potential of these approaches and examine their possible consequences for pathogen evolution. To guarantee a longer half-life of these alternatives to directly killing pathogens, and to gain a full understanding of their population-level consequences, the authors encourage future work to incorporate evolutionary perspectives into the development of these treatments.

Story tags: 

Please tell us what you think about this website !

What do you think of the Edinburgh Infectious Diseases website?  We would be very grateful if you could spare 2 minutes to help us improve the useability and look of our pages. Thank you for your help !