Adriano Rossi in the Centre for Inflammation Research is awarded £2.5million MRC Programme Grant

Many congratulations to Adriano Rossi and Chris Haslett in the Centre for Inflammation Research, Queen's Medical Research Institute, on the award of a £2.5M programme grant from the Medical Research Council.

Their new research will investigate "The Role of Cyclin-Dependent Kinase-9 Inhibition in Promoting the Resolution of Chronic Inflammation".

Having shown that cyclin-dependent kinase (CDK) inhibitor drugs induce resolution in acute inflammation and have similar potential in chronic inflammatory conditions, it is  hypothesised that CDK9 is pivotal in maintaining chronic inflammation. The programme of work will employ models of inflammation to investigate CDK inhibitor drugs targeting CDK9 to promote the resolution of chronic inflammatory/scarring diseases of the lungs and other organs. This, together with studies using human inflammatory macrophages, will provide a platform for drug discovery for the treatment of chronic inflammatory/scarring diseases.

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