Human MRSA strain originated in cattle
A type of MRSA found in humans originated in cattle at least 40 years ago, new research has found. The study provides clear evidence that livestock were the original source of an MRSA strain which is now widespread in people.
Methicillin Resistant Staphylococcus aureus
Edinburgh Infectious Diseases researchers based at the Roslin Institute studied the genetic make-up of more than 40 strains of a bacterium - called Staphylococcus aureus - that can build up antibiotic resistance to develop into Methicillin Resistant S. aureus (MRSA).
At least two genetic subtypes of the bacterium, which have become endemic in people, have been traced back to cattle.
Researchers say the most likely scenario is that the bug crossed over from cattle to people through direct contact - perhaps through people working with farm animals.
Human infections caused by bacteria being transmitted directly from livestock are well known to occur. However this is the first clear genetic evidence of subtypes of Staph. aureus which jumped from cattle and developed the capacity to transmit widely among human populations.
- Professor Ross Fitzgerald, Chair in Molecular Bacteriology, The Roslin Institute
The research will help scientists find out how the bacteria are able to spread and cause disease in humans and to prevent further strains from jumping from livestock.
After switching to human hosts, the Staphylococcus aureus bacterium became resistant to the antibiotic methicillin and developed into methicillin-resistant Staphylococcus aureus or MRSA. The bacteria also acquired the ability to avoid attack by the human immune system. However, these bacteria that originated in cattle do not appear to be more aggressive or more resistant to antibiotics than other MRSA affecting humans.
This research provides insight into how some strains of MRSA have evolved and help us better understand how they have adapted to cause disease in different host species.
- Laura Spoor, The Roslin Institute and first author on the research paper
The study is published in the journal mBio
The research was funded by the Biotecnology and Biological Sciences Research Council (BBSRC) and the Swan-Riddell Ker Memorial PhD studentship. It involved The Roslin Institute, the University of Cambridge, National Food Institute Denmark, Public Health England and the Statens Serum Institute, Denmark.
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